TY - JOUR
T1 - Antihyperalgesic activity of quillaic acid obtained from Quillaja saponaria mol.
AU - Rodríguez-Díaz, Maité
AU - Arrau, Sylvia
AU - Cassels, Bruce K.
AU - Valenzuela-Barra, Gabriela
AU - Delporte, Carla
AU - Barriga, Andrés
AU - Miranda, Hugo F.
N1 - Funding Information:
This work was partially supported by Fondecyt Grant No. 1080174, Fondecyt 1130155 and ICM Grant No. P05-001-F.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Background: Quillaja saponaria Mol. bark contains a high concentration of triterpene saponins that have been used for centuries as a cleansing, antiinflammatory and analgesic agent in Chilean folk medicine. In earlier studies, in mice, both the anti-inflammatory as well as the antinociceptive effect of the major sapogenin, quillaic acid have been demonstrated (QA). Objective: To determine the antihyperalgesic effect of QA one and seven days after itpl administration of complete Freund's adjuvant (CFA) in male mice using the hot plate test in the presence of complete Freund's adjuvant (HP/CFA) as an acute and chronic skeletal muscle pain model. Methods: The present study evaluated the antihyperalgesic activity of QA against acute and chronic skeletal muscle pain models in mice using the hot plate test in the presence of complete Freund's adjuvant (HP/CFA), at 24 h (acute assay) and 7 days (chronic assay), with dexketoprofen (DEX) as the reference drug. Results: In acute and chronic skeletal muscle pain assays, QA at 30 mg/kg ip elicited its maximal antihyperalgesic effects (65.0% and 53.4%) at 24 h and 7 days, respectively. The maximal effect of DEX (99.0 and 94.1 at 24 h and 7 days, respectively) was induced at 100 mg/kg. Conclusion: QA and DEX elicit dose-dependent antihyperalgesic effects against acute and chronic skeletal muscle pain, but QA is more potent than DEX in the early and late periods of inflammatory pain induced by CFA.
AB - Background: Quillaja saponaria Mol. bark contains a high concentration of triterpene saponins that have been used for centuries as a cleansing, antiinflammatory and analgesic agent in Chilean folk medicine. In earlier studies, in mice, both the anti-inflammatory as well as the antinociceptive effect of the major sapogenin, quillaic acid have been demonstrated (QA). Objective: To determine the antihyperalgesic effect of QA one and seven days after itpl administration of complete Freund's adjuvant (CFA) in male mice using the hot plate test in the presence of complete Freund's adjuvant (HP/CFA) as an acute and chronic skeletal muscle pain model. Methods: The present study evaluated the antihyperalgesic activity of QA against acute and chronic skeletal muscle pain models in mice using the hot plate test in the presence of complete Freund's adjuvant (HP/CFA), at 24 h (acute assay) and 7 days (chronic assay), with dexketoprofen (DEX) as the reference drug. Results: In acute and chronic skeletal muscle pain assays, QA at 30 mg/kg ip elicited its maximal antihyperalgesic effects (65.0% and 53.4%) at 24 h and 7 days, respectively. The maximal effect of DEX (99.0 and 94.1 at 24 h and 7 days, respectively) was induced at 100 mg/kg. Conclusion: QA and DEX elicit dose-dependent antihyperalgesic effects against acute and chronic skeletal muscle pain, but QA is more potent than DEX in the early and late periods of inflammatory pain induced by CFA.
KW - Antihyperalgesic activity
KW - Complete Freund's adjuvant
KW - DEX
KW - Quillaic acid
KW - Quillaja saponaria
KW - Skeletal muscle pain
UR - http://www.scopus.com/inward/record.url?scp=85070969839&partnerID=8YFLogxK
U2 - 10.2174/1568026619666190509115741
DO - 10.2174/1568026619666190509115741
M3 - Article
C2 - 31072292
AN - SCOPUS:85070969839
SN - 1568-0266
VL - 19
SP - 927
EP - 930
JO - Current Topics in Medicinal Chemistry
JF - Current Topics in Medicinal Chemistry
IS - 11
ER -