Antigen engineering in Yeast: Synthesis and assembly of hybrid hepatitis b surface antigen-herpes simplex 1 gd particles

Pablo Valenzuela; Doris Coit; M. Angelica Medina-Selby; Ching H. Kuo; Gary Van Nest; Rae Lyn Burke; Paulina Bull; Mickey S. Urdea; Pierre V. Graves

doi:10.1038/nbt0485-323

Antigen engineering in Yeast: Synthesis and assembly of hybrid hepatitis b surface antigen-herpes simplex 1 gd particles

Pablo Valenzuela, Doris Coit, M. Angelica Medina-Selby, Ching H. Kuo, Gary Van Nest, Rae Lyn Burke, Paulina Bull, Mickey S. Urdea, Pierre V. Graves

Life Sciences School

Research output: Contribution to journal › Article › peer-review

68 Citations (Scopus)

Abstract

A new approach for antigen presentation and polyvalent vaccines is tested. The idea is to recombine the gene of a second immunogen with that of hepatitis B surface antigen so that the second immunogen is assembled into, and presented on the surface of the HBsAg particle. We describe here the synthesis and assembly in yeast of a model hybrid particle containing both, hepatitis B virus and herpes simplex virus surface antigens.

Original language	English
Pages (from-to)	323-326
Number of pages	4
Journal	Bio/Technology
Volume	3
Issue number	4
DOIs	https://doi.org/10.1038/nbt0485-323
Publication status	Published - 1 Jan 1985

ASJC Scopus subject areas

Biotechnology

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/nbt0485-323

Cite this

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title = "Antigen engineering in Yeast: Synthesis and assembly of hybrid hepatitis b surface antigen-herpes simplex 1 gd particles",

abstract = "A new approach for antigen presentation and polyvalent vaccines is tested. The idea is to recombine the gene of a second immunogen with that of hepatitis B surface antigen so that the second immunogen is assembled into, and presented on the surface of the HBsAg particle. We describe here the synthesis and assembly in yeast of a model hybrid particle containing both, hepatitis B virus and herpes simplex virus surface antigens.",

author = "Pablo Valenzuela and Doris Coit and Medina-Selby, {M. Angelica} and Kuo, {Ching H.} and {Van Nest}, Gary and Burke, {Rae Lyn} and Paulina Bull and Urdea, {Mickey S.} and Graves, {Pierre V.}",

year = "1985",

month = jan,

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doi = "10.1038/nbt0485-323",

language = "English",

volume = "3",

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journal = "Nature Biotechnology",

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Antigen engineering in Yeast : Synthesis and assembly of hybrid hepatitis b surface antigen-herpes simplex 1 gd particles. / Valenzuela, Pablo; Coit, Doris; Medina-Selby, M. Angelica; Kuo, Ching H.; Van Nest, Gary; Burke, Rae Lyn; Bull, Paulina; Urdea, Mickey S.; Graves, Pierre V.

In: Bio/Technology, Vol. 3, No. 4, 01.01.1985, p. 323-326.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Antigen engineering in Yeast

T2 - Synthesis and assembly of hybrid hepatitis b surface antigen-herpes simplex 1 gd particles

AU - Valenzuela, Pablo

AU - Coit, Doris

AU - Medina-Selby, M. Angelica

AU - Kuo, Ching H.

AU - Van Nest, Gary

AU - Burke, Rae Lyn

AU - Bull, Paulina

AU - Urdea, Mickey S.

AU - Graves, Pierre V.

PY - 1985/1/1

Y1 - 1985/1/1

N2 - A new approach for antigen presentation and polyvalent vaccines is tested. The idea is to recombine the gene of a second immunogen with that of hepatitis B surface antigen so that the second immunogen is assembled into, and presented on the surface of the HBsAg particle. We describe here the synthesis and assembly in yeast of a model hybrid particle containing both, hepatitis B virus and herpes simplex virus surface antigens.

AB - A new approach for antigen presentation and polyvalent vaccines is tested. The idea is to recombine the gene of a second immunogen with that of hepatitis B surface antigen so that the second immunogen is assembled into, and presented on the surface of the HBsAg particle. We describe here the synthesis and assembly in yeast of a model hybrid particle containing both, hepatitis B virus and herpes simplex virus surface antigens.

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DO - 10.1038/nbt0485-323

M3 - Article

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JO - Nature Biotechnology

JF - Nature Biotechnology

SN - 1087-0156

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Antigen engineering in Yeast: Synthesis and assembly of hybrid hepatitis b surface antigen-herpes simplex 1 gd particles

Abstract

ASJC Scopus subject areas

UN SDGs

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