Antigen engineering in Yeast: Synthesis and assembly of hybrid hepatitis b surface antigen-herpes simplex 1 gd particles

Pablo Valenzuela, Doris Coit, M. Angelica Medina-Selby, Ching H. Kuo, Gary Van Nest, Rae Lyn Burke, Paulina Bull, Mickey S. Urdea, Pierre V. Graves

Research output: Contribution to journalArticlepeer-review

68 Citations (Scopus)

Abstract

A new approach for antigen presentation and polyvalent vaccines is tested. The idea is to recombine the gene of a second immunogen with that of hepatitis B surface antigen so that the second immunogen is assembled into, and presented on the surface of the HBsAg particle. We describe here the synthesis and assembly in yeast of a model hybrid particle containing both, hepatitis B virus and herpes simplex virus surface antigens.

Original languageEnglish
Pages (from-to)323-326
Number of pages4
JournalBio/Technology
Volume3
Issue number4
DOIs
Publication statusPublished - 1 Jan 1985

ASJC Scopus subject areas

  • Biotechnology

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