Androgen receptor in human endothelial cells

Verónica Torres-Estay, Daniela V. Carreño, Ignacio F. San Francisco, Paula Sotomayor, Alejandro S. Godoy, Gary J. Smith

Research output: Contribution to journalReview articlepeer-review

37 Citations (Scopus)

Abstract

Androgen receptor (AR) is a ligand-inducible transcription factor, and a member of the steroid-thyroid-retinoid receptor superfamily, that mediates the biological effects of androgens in a wide range of physiological and pathological processes. AR expression was identified in vascular cells nearly 20 years ago, and recent research has shown that AR mediates a variety of actions of androgens in endothelial and vascular smooth muscle cells. In this mini-review, we review evidence indicating the importance of AR in human endothelial cell (HUVEC) homeostatic and pathogenic processes. Although a role for AR in the modulation of HUVEC biology is evident, the molecular mechanisms by which AR regulates HUVEC homeostasis and disease processes are not fully understood. Understanding these mechanisms could provide critical insights into the processes of pathogenesis of diseases ranging from cardiovascular disease to cancer that are major causes of human morbidity and mortality.

Original languageEnglish
Pages (from-to)R131-R137
JournalJournal of Endocrinology
Volume224
Issue number3
DOIs
Publication statusPublished - 2015

Keywords

  • Androgen receptor
  • Angiogenesis
  • Cancer
  • Endothelium

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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