Analgesic effect of benzodiazepines and flumazenil

F. Sierralta, H. F. Miranda

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

1. 1. In the present work the analgesic effect of benzodiazepines (BZD) and flumazenil (FLU) using the writhing test in mice was studied. 2. 2. Intracerebroventricular administration of BZD exhibited a dose-dependent antinociceptive effect when compared to control value. 3. 3. Intracerebroventricular administration of FLU induced a dose-dependent antinociceptive action that was not antagonized by naloxone (NX). 4. 4. BZD administered as subcutaneous pellets produced an antinociceptive action in the writhing test, when compared to control mice, only at relative high doses and was partially antagonized by naloxone. 5. 5. These findings could be explained assuming that NX and/or FLU have partial agonist properties in a common receptor which mediates the antinociceptive action. 6. 6. The antinociceptive action of BZD could be related to an increased release of adenosine, which by itself has analgesic effects.

Original languageEnglish
Pages (from-to)739-742
Number of pages4
JournalGeneral Pharmacology
Volume23
Issue number4
DOIs
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Pharmacology

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