Analgesic action of clonixin, nifedipine and morphine using the formalin test

D. Bustamante, H. F. Miranda, T. Pelissier, C. Paeile

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

1. 1. The analgesic effect of C1X, nifedipine, metamizol, indoprofen and morphine in the pain induced by formalin injection (formalin test) was studied. 2. 2. Attempts to demonstrate tolerance to C1X were unsuccessful. 3. 3. In the analgesic test nifedipine and morphine are approximately 10 times more potent than C1X. 4. 4. The present results suggest that the analgesic action of C1X is not mediated by μ1, δ or κ-opioid receptors and the anti-nociceptive effect of nifedipine may be associated with the blockade of the transmembrane inward movements of calcium.

Original languageEnglish
Pages (from-to)319-322
Number of pages4
JournalGeneral Pharmacology
Volume20
Issue number3
DOIs
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Pharmacology

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