Advanced glycation end products: New clinical and molecular perspectives

Juan Salazar, Carla Navarro, Ángel Ortega, Manuel Nava, Daniela Morillo, Wheeler Torres, Marlon Hernández, Mayela Cabrera, Lissé Angarita, Rina Ortiz, Maricarmen Chacín, Luis D’marco, Valmore Bermúdez

Research output: Contribution to journalArticlepeer-review

Abstract

Diabetes mellitus (DM) is considered one of the most massive epidemics of the twenty-first century due to its high mortality rates caused mainly due to its complications; therefore, the early identification of such complications becomes a race against time to establish a prompt diag-nosis. The research of complications of DM over the years has allowed the development of numer-ous alternatives for diagnosis. Among these emerge the quantification of advanced glycation end products (AGEs) given their increased levels due to chronic hyperglycemia, while also being related to the induction of different stress-associated cellular responses and proinflammatory mechanisms involved in the progression of chronic complications of DM. Additionally, the investigation for more valuable and safe techniques has led to developing a newer, noninvasive, and effective tool, termed skin fluorescence (SAF). Hence, this study aimed to establish an update about the molecular mechanisms induced by AGEs during the evolution of chronic complications of DM and describe the newer measurement techniques available, highlighting SAF as a possible tool to measure the risk of developing DM chronic complications.

Original languageEnglish
Article number7236
JournalInternational Journal of Environmental Research and Public Health
Volume18
Issue number14
DOIs
Publication statusPublished - 2 Jul 2021

Keywords

  • Advanced glycation end products
  • Chronic complications
  • Diabetes mellitus
  • Skin fluorescence

ASJC Scopus subject areas

  • Pollution
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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