Adult hippocampal neurogenesis in aging and Alzheimer's disease

Lorena Varela-Nallar, Florencia C. Aranguiz, Ana C. Abbott, Paula G. Slater, Nibaldo C. Inestrosa

Research output: Contribution to journalReview articlepeer-review

42 Citations (Scopus)

Abstract

Adult neurogenesis occurs in the subgranular zone of the hippocampal dentate gyrus and the subventricular zone of the lateral ventricles. This process is highly regulated by intrinsic and extrinsic factors, which may control the proliferation and/or maturation of neural progenitor cells. Adult-born neurons are integrated in preexisting networks and may have functional implications for adult brain. Here we attempt to summarize relevant findings concerning the physiological role of adult neurogenesis mainly focused on the subgranular zone, and to discuss the reduced neurogenesis observed during aging and the factors that have been involved in this phenomenon. Finally, we focus on hippocampal neurogenesis in Alzheimer's disease, reviewing animal models of the disease used for the study of this process and the conclusions that have been drawn in this context.

Original languageEnglish
Pages (from-to)284-296
Number of pages13
JournalBirth Defects Research Part C - Embryo Today: Reviews
Volume90
Issue number4
DOIs
Publication statusPublished - Dec 2010

Keywords

  • Adult neurogenesis
  • Aging
  • Alzheimer's disease

ASJC Scopus subject areas

  • Embryology
  • Developmental Biology
  • Medicine(all)

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