Acyldepsipeptide antibiotics as a potential therapeutic agent against Clostridium difficile recurrent infections

Fernando Gil, Daniel Paredes-Sabja

Research output: Contribution to journalReview articlepeer-review

8 Citations (Scopus)

Abstract

Alternative antimicrobial therapies based on acyldepsipeptides may hold promising results, based on the fact that they have shown to efficiently eradicate persister cells, stationary cells and cell in biofilm structures of several pathogenic bacteria from the infected host. Clostridium difficile infection is considered the result of extensive hospital use of expanded-spectrum antibiotics, which cause dysbiosis of the intestinal microbiota, enhancing susceptibility to infection and persistence. Considering the urgent need for the development of novel and efficient antimicrobial strategies against C. difficile, we review the potential application to treat C. difficile infections of acyldepsipeptides family of antibiotics, its mechanism of action and current developmental stages.

Original languageEnglish
Pages (from-to)1179-1189
Number of pages11
JournalFuture Microbiology
Volume11
Issue number9
DOIs
Publication statusPublished - 1 Sep 2016

Keywords

  • ADEP
  • antibiotic tolerance
  • Clostridium difficile

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

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