Acompanhamento de mulheres com células escamosas atípicas não pode excluir lesão intraepitelial de alto grau (ASC-H)

Translated title of the contribution: Follow-up of women with atypical squamous cells cannot exclude high-grade squamous intraepithelial lesions (ASC-H)

Fanny López-Alegría, Dino Soares De Lorenzi, Orlando Poblete Quezada

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Context and Objective: The concept that the presence of atypical squamous cells cannot exclude high-grade squamous intraepithelial lesions (ASC-H) was introduced in the 2001 Bethesda System of cervical cytology classification. This nomenclature defines cervical cancer precursor lesions. The objective of this study was to investigate the colpocytological-histological results from a three-year follow-up conducted on a cohort of women with reports of ASC-H who were attended during 2005-2006 at clinics of the Southern Metropolitan Healthcare Service of Santiago, Chile. Design and Setting: Prospective cohort study at primary healthcare clinics in Santiago, Chile. Methods: Colpocytological-histological follow-up was conducted over a three-year period on 92 women with cytological reports of ASC-H who were attended at primary healthcare clinics during 2005-2006. Results: At the end of the follow-up period, high-grade lesions were evaluated and the following outcomes were observed: seven women presented invasive cancer (7.6%), 49 presented high-grade lesions (53.3%), 26 presented low-grade lesions (28.2%) and 10 presented normal results (10.9%). The "Conditional Probabilities Tree Diagram" was used to show the results from tests and the times of lesion detection. It demonstrated that, after a first report of ASC-H, clinical management needed to be interventionist. Conclusion: The follow-up on our cohort of women showed that the majority of uncertain ASC-H diagnoses (82.6%) had abnormal colposcopic results and that during the follow-up using ASC-H smears, two out of every three women developed high-grade lesions.

Translated title of the contributionFollow-up of women with atypical squamous cells cannot exclude high-grade squamous intraepithelial lesions (ASC-H)
Original languagePortuguese
Pages (from-to)15-22
Number of pages8
JournalSao Paulo Medical Journal
Volume132
Issue number1
DOIs
Publication statusPublished - 2014

ASJC Scopus subject areas

  • Medicine(all)

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