Abstract
Protein therapeutics have gained attention recently for treatment of a myriad of human diseases due to their high potency and unique mechanisms of action. We present the development of a novel polymeric thermosponge nanoparticle for efficient delivery of labile proteins using a solvent-free polymer thermo-expansion mechanism with clinical potential, capable of effectively delivering a range of therapeutic proteins in a sustained manner with no loss of bioactivity, with improved biological half-lives and efficacy in vivo.
Original language | English |
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Pages (from-to) | 6449-6455 |
Number of pages | 7 |
Journal | Nano Letters |
Volume | 14 |
Issue number | 11 |
DOIs | |
Publication status | Published - 12 Nov 2014 |
Keywords
- Nanoparticles
- biologics
- solvent-free
- therapeutic proteins
- thermosponge
ASJC Scopus subject areas
- Bioengineering
- General Chemistry
- General Materials Science
- Condensed Matter Physics
- Mechanical Engineering