A solvent-free thermosponge nanoparticle platform for efficient delivery of labile proteins

Won Il Choi, Nazila Kamaly, Lorena Riol-Blanco, In Hyun Lee, Jun Wu, Archana Swami, Cristian Vilos, Basit Yameen, Mikyung Yu, Jinjun Shi, Ira Tabas, Ulrich H. Von Andrian, Sangyong Jon, Omid C. Farokhzad

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)

Abstract

Protein therapeutics have gained attention recently for treatment of a myriad of human diseases due to their high potency and unique mechanisms of action. We present the development of a novel polymeric thermosponge nanoparticle for efficient delivery of labile proteins using a solvent-free polymer thermo-expansion mechanism with clinical potential, capable of effectively delivering a range of therapeutic proteins in a sustained manner with no loss of bioactivity, with improved biological half-lives and efficacy in vivo.

Original languageEnglish
Pages (from-to)6449-6455
Number of pages7
JournalNano Letters
Volume14
Issue number11
DOIs
Publication statusPublished - 12 Nov 2014

Keywords

  • Nanoparticles
  • biologics
  • solvent-free
  • therapeutic proteins
  • thermosponge

ASJC Scopus subject areas

  • Bioengineering
  • General Chemistry
  • General Materials Science
  • Condensed Matter Physics
  • Mechanical Engineering

Fingerprint

Dive into the research topics of 'A solvent-free thermosponge nanoparticle platform for efficient delivery of labile proteins'. Together they form a unique fingerprint.

Cite this