A Single-Nucleotide Polymorphism of α V β₃ Integrin Is Associated with the Andes Virus Infection Susceptibility

Constanza Martínez-Valdebenito, Jenniffer Angulo, Nicole Le Corre, Claudia Marco, Cecilia Vial, Juan Francisco Miquel, Jaime Cerda, Gregory Mertz, Pablo Vial, Marcelo Lopez-Lastra, Marcela Ferrés

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Abstract

The AndesOrthohantavirus (ANDV), which causes the hantavirus cardiopulmonary syndrome, enters cells via integrins, and a change from leucine to proline at residue 33 in the PSI domain (L33P), impairs ANDV recognition. We assessed the association between this human polymorphism and ANDV infection. We defined susceptible and protective genotypes as "TT" (coding leucine) and "CC" (coding proline), respectively. TT was present at a rate of 89.2% (66/74) among the first cohort of ANDV cases and at 60% (63/105) among exposed close-household contacts, who remained uninfected (p < 0.05). The protective genotype (CC) was absent in all 85 ANDV cases, in both cohorts, and was present at 11.4% of the exposed close-household contacts who remained uninfected. Logistic regression modeling for risk of infection had an OR of 6.2⁻12.6 (p < 0.05) in the presence of TT and well-known ANDV risk activities. Moreover, an OR of 7.3 was obtained when the TT condition was analyzed for two groups exposed to the same environmental risk. Host genetic background was found to have an important role in ANDV infection susceptibility, in the studied population.

Original languageEnglish
JournalViruses
Volume11
Issue number2
DOIs
Publication statusPublished - 20 Feb 2019
Externally publishedYes

Keywords

  • ANDV
  • Hantavirus
  • L33P
  • PSI domain
  • rs5918
  • SNP

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

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    Martínez-Valdebenito, C., Angulo, J., Le Corre, N., Marco, C., Vial, C., Miquel, J. F., Cerda, J., Mertz, G., Vial, P., Lopez-Lastra, M., & Ferrés, M. (2019). A Single-Nucleotide Polymorphism of α V β₃ Integrin Is Associated with the Andes Virus Infection Susceptibility. Viruses, 11(2). https://doi.org/10.3390/v11020169