A physiological approach to understand the role of respiratory effort in the progression of lung injury in SARS-CoV-2 infection

Pablo Cruces, Jaime Retamal, Daniel E. Hurtado, Benjamín Erranz, Pablo Iturrieta, Carlos González, Franco Díaz

Research output: Contribution to journalReview articlepeer-review

14 Citations (Scopus)

Abstract

Deterioration of lung function during the first week of COVID-19 has been observed when patients remain with insufficient respiratory support. Patient self-inflicted lung injury (P-SILI) is theorized as the responsible, but there is not robust experimental and clinical data to support it. Given the limited understanding of P-SILI, we describe the physiological basis of P-SILI and we show experimental data to comprehend the role of regional strain and heterogeneity in lung injury due to increased work of breathing. In addition, we discuss the current approach to respiratory support for COVID-19 under this point of view.

Original languageEnglish
Article number494
JournalCritical Care
Volume24
Issue number1
DOIs
Publication statusPublished - 10 Aug 2020

Keywords

  • COVID-19
  • Lung strain
  • Mechanical ventilation
  • P-SILI
  • SARS-CoV2
  • Work of breathing

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Fingerprint

Dive into the research topics of 'A physiological approach to understand the role of respiratory effort in the progression of lung injury in SARS-CoV-2 infection'. Together they form a unique fingerprint.

Cite this