A physiological approach to understand the role of respiratory effort in the progression of lung injury in SARS-CoV-2 infection

Pablo Cruces; Jaime Retamal; Daniel E. Hurtado; Benjamín Erranz; Pablo Iturrieta; Carlos González; Franco Díaz

doi:10.1186/s13054-020-03197-7

A physiological approach to understand the role of respiratory effort in the progression of lung injury in SARS-CoV-2 infection

Pablo Cruces, Jaime Retamal, Daniel E. Hurtado, Benjamín Erranz, Pablo Iturrieta, Carlos González, Franco Díaz

Research output: Contribution to journal › Review article › peer-review

73 Citations (Scopus)

Abstract

Deterioration of lung function during the first week of COVID-19 has been observed when patients remain with insufficient respiratory support. Patient self-inflicted lung injury (P-SILI) is theorized as the responsible, but there is not robust experimental and clinical data to support it. Given the limited understanding of P-SILI, we describe the physiological basis of P-SILI and we show experimental data to comprehend the role of regional strain and heterogeneity in lung injury due to increased work of breathing. In addition, we discuss the current approach to respiratory support for COVID-19 under this point of view.

Original language	English
Article number	494
Journal	Critical Care
Volume	24
Issue number	1
DOIs	https://doi.org/10.1186/s13054-020-03197-7
Publication status	Published - 10 Aug 2020

Keywords

COVID-19
Lung strain
Mechanical ventilation
P-SILI
SARS-CoV2
Work of breathing

ASJC Scopus subject areas

Critical Care and Intensive Care Medicine

Access to Document

10.1186/s13054-020-03197-7

Cite this

@article{3df766e1b54744bcb9363883e0c647dd,

title = "A physiological approach to understand the role of respiratory effort in the progression of lung injury in SARS-CoV-2 infection",

abstract = "Deterioration of lung function during the first week of COVID-19 has been observed when patients remain with insufficient respiratory support. Patient self-inflicted lung injury (P-SILI) is theorized as the responsible, but there is not robust experimental and clinical data to support it. Given the limited understanding of P-SILI, we describe the physiological basis of P-SILI and we show experimental data to comprehend the role of regional strain and heterogeneity in lung injury due to increased work of breathing. In addition, we discuss the current approach to respiratory support for COVID-19 under this point of view.",

keywords = "COVID-19, Lung strain, Mechanical ventilation, P-SILI, SARS-CoV2, Work of breathing",

author = "Pablo Cruces and Jaime Retamal and Hurtado, {Daniel E.} and Benjam{\'i}n Erranz and Pablo Iturrieta and Carlos Gonz{\'a}lez and Franco D{\'i}az",

note = "Publisher Copyright: {\textcopyright} 2020 The Author(s).",

year = "2020",

month = aug,

day = "10",

doi = "10.1186/s13054-020-03197-7",

language = "English",

volume = "24",

journal = "Critical Care",

issn = "1466-609X",

publisher = "Springer Science + Business Media",

number = "1",

}

TY - JOUR

T1 - A physiological approach to understand the role of respiratory effort in the progression of lung injury in SARS-CoV-2 infection

AU - Cruces, Pablo

AU - Retamal, Jaime

AU - Hurtado, Daniel E.

AU - Erranz, Benjamín

AU - Iturrieta, Pablo

AU - González, Carlos

AU - Díaz, Franco

PY - 2020/8/10

Y1 - 2020/8/10

N2 - Deterioration of lung function during the first week of COVID-19 has been observed when patients remain with insufficient respiratory support. Patient self-inflicted lung injury (P-SILI) is theorized as the responsible, but there is not robust experimental and clinical data to support it. Given the limited understanding of P-SILI, we describe the physiological basis of P-SILI and we show experimental data to comprehend the role of regional strain and heterogeneity in lung injury due to increased work of breathing. In addition, we discuss the current approach to respiratory support for COVID-19 under this point of view.

AB - Deterioration of lung function during the first week of COVID-19 has been observed when patients remain with insufficient respiratory support. Patient self-inflicted lung injury (P-SILI) is theorized as the responsible, but there is not robust experimental and clinical data to support it. Given the limited understanding of P-SILI, we describe the physiological basis of P-SILI and we show experimental data to comprehend the role of regional strain and heterogeneity in lung injury due to increased work of breathing. In addition, we discuss the current approach to respiratory support for COVID-19 under this point of view.

KW - COVID-19

KW - Lung strain

KW - Mechanical ventilation

KW - P-SILI

KW - SARS-CoV2

KW - Work of breathing

UR - http://www.scopus.com/inward/record.url?scp=85089332186&partnerID=8YFLogxK

U2 - 10.1186/s13054-020-03197-7

DO - 10.1186/s13054-020-03197-7

M3 - Review article

C2 - 32778136

AN - SCOPUS:85089332186

SN - 1466-609X

VL - 24

JO - Critical Care

JF - Critical Care

IS - 1

M1 - 494

ER -

A physiological approach to understand the role of respiratory effort in the progression of lung injury in SARS-CoV-2 infection

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this