A multicentre efficacy and safety study of the single contraceptive implant Implanon®

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129 Citations (Scopus)

Abstract

An open, multicentre study was performed to assess efficacy, safety and acceptability of the single-rod contraceptive implant Implanon®. The study involved 635 young healthy women, who were sexually active and of childbearing potential. The women were followed up every 3 months over the entire study period. Originally the study was designed for 2 years, but was extended to 3 years in a group of 147 women from two centres. Altogether, 21 centres in nine different countries participated. The average age of the women was 29 years (range 18-42 years), of whom 83.5% had been pregnant in the past. No pregnancy occurred during treatment with Implanon®, resulting in a Pearl Index of 0 (95% confidence interval: 0.0-0.2). In the first 2 years, 31% had discontinued the treatment. Of the 147 women in the study extension, nine discontinued (6%) treatment. Bleeding irregularities was the main reason for discontinuation during the first 2 years of use (17.2%) and adverse experiences in the third year (3.4%). Implant insertion and removal were fast and uncomplicated in the vast majority (97%) of cases. Return of fertility was prompt. In conclusion, Implanon® has excellent contraceptive action during its lifetime of 3 years. The safety profile is acceptable and not essentially different from progestogens in general.

Original languageEnglish
Pages (from-to)976-981
Number of pages6
JournalHuman Reproduction
Volume14
Issue number4
DOIs
Publication statusPublished - 1999

Keywords

  • Contraceptive implant
  • Efficacy
  • Implanon®
  • Safety
  • Vaginal bleeding

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

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