TY - JOUR
T1 - A longitudinal study on cortisol, prolactin and thyroid hormones in users of norplantR subdermal implants or a copper T device
AU - Díaz, S.
AU - Pavez, M.
AU - Brandeis, A.
AU - Cárdenas, H.
AU - Croxatto, H. B.
PY - 1989/1/1
Y1 - 1989/1/1
N2 - A longitudinal study was undertaken to assess PRL, cortisol, TSH, T3 and T4 levels in NORPLANT4 implant users (n = 22) and Copper T users (n = 20). Participants were healthy women with no contraindication for hormonal contraception. Samples were drawn at 0930 to 1000 h twice pretreatment and at month 2, 4, 6, 12, 24 and 36 after insertion. At the second treatment month, a second sample was obtained at 1600 h to assess cortisol diurnal variation. Hormones were measured by RIA. Values for all hormones were similar in NORPLANTR and Copper T users. No significant changes occurred throughout the study period. Elevated PRL levels (>500 mU/1) were found in three women from each group before and during treatment but no clinical evidence of hyperprolactinemia was detected. The results of this study reassure that long-term use of NORPLANTR implants do not impair plasma levels of cortisol, prolactin and thyroid hormones.
AB - A longitudinal study was undertaken to assess PRL, cortisol, TSH, T3 and T4 levels in NORPLANT4 implant users (n = 22) and Copper T users (n = 20). Participants were healthy women with no contraindication for hormonal contraception. Samples were drawn at 0930 to 1000 h twice pretreatment and at month 2, 4, 6, 12, 24 and 36 after insertion. At the second treatment month, a second sample was obtained at 1600 h to assess cortisol diurnal variation. Hormones were measured by RIA. Values for all hormones were similar in NORPLANTR and Copper T users. No significant changes occurred throughout the study period. Elevated PRL levels (>500 mU/1) were found in three women from each group before and during treatment but no clinical evidence of hyperprolactinemia was detected. The results of this study reassure that long-term use of NORPLANTR implants do not impair plasma levels of cortisol, prolactin and thyroid hormones.
UR - http://www.scopus.com/inward/record.url?scp=0024446374&partnerID=8YFLogxK
U2 - 10.1016/0010-7824(89)90056-5
DO - 10.1016/0010-7824(89)90056-5
M3 - Article
C2 - 2510969
AN - SCOPUS:0024446374
SN - 0010-7824
VL - 40
SP - 505
EP - 517
JO - Contraception
JF - Contraception
IS - 4
ER -