A longitudinal study was undertaken to assess PRL, cortisol, TSH, T3 and T4 levels in NORPLANT4 implant users (n = 22) and Copper T users (n = 20). Participants were healthy women with no contraindication for hormonal contraception. Samples were drawn at 0930 to 1000 h twice pretreatment and at month 2, 4, 6, 12, 24 and 36 after insertion. At the second treatment month, a second sample was obtained at 1600 h to assess cortisol diurnal variation. Hormones were measured by RIA. Values for all hormones were similar in NORPLANTR and Copper T users. No significant changes occurred throughout the study period. Elevated PRL levels (>500 mU/1) were found in three women from each group before and during treatment but no clinical evidence of hyperprolactinemia was detected. The results of this study reassure that long-term use of NORPLANTR implants do not impair plasma levels of cortisol, prolactin and thyroid hormones.
ASJC Scopus subject areas
- Obstetrics and Gynaecology