JAIME EDUARDO VILLEGAS OLAVARRIA

Bachelor in Biologicals Science, PhD in Sciences

    • 321 Citations
    • 11 h-Index
    19972019
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    Research Output 1997 2019

    • 321 Citations
    • 11 h-Index
    • 18 Article
    • 2 Chapter
    • 1 Editorial
    2019

    HPV-18 E2 protein downregulates antisense noncoding mitochondrial RNA-2, delaying replicative senescence of human keratinocytes

    Villota, C., Varas-Godoy, M., Jeldes, E., Campos, A., Villegas, J., Borgna, V., Burzio, L. O. & Burzio, V. A., 1 Jan 2019, In : Aging. 11, 1, p. 33-47 15 p.

    Research output: Contribution to journalArticle

    Antisense RNA
    Untranslated RNA
    Cell Aging
    Keratinocytes
    Down-Regulation

    Mitochondrial ncRNA targeting induces cell cycle arrest and tumor growth inhibition of MDA-MB-231 breast cancer cells through reduction of key cell cycle progression factors

    Fitzpatrick, C., Bendek, M. F., Briones, M., Farfán, N., Silva, V. A., Nardocci, G., Montecino, M., Boland, A., Deleuze, J. F., Villegas, J., Villota, C., Silva, V., Lobos-Gonzalez, L., Borgna, V., Barrey, E., Burzio, L. O. & Burzio, V. A., 1 Jun 2019, In : Cell Death and Disease. 10, 6, 423.

    Research output: Contribution to journalArticle

    Open Access
    Cell Cycle Checkpoints
    Cell Cycle
    Breast Neoplasms
    MicroRNAs
    Growth
    2017

    Cervical cancer, human papillomavirus and vaccines: assessment of the information retrieved from general knowledge websites in Chile

    Lopez, C. S., Krauskopf, E., Villota, C. E., Burzio, L. O. & Villegas, J. E., 1 Jul 2017, In : Public Health. 148, p. 19-24 6 p.

    Research output: Contribution to journalArticle

    Papillomavirus Vaccines
    Chile
    Uterine Cervical Neoplasms
    Health
    Cause of Death

    Different cancers, same target?

    Villegas, J., Borgna, V. & Burzio, V. A., 1 Jan 2017, In : Aging. 9, 8, p. 1853-1854 2 p.

    Research output: Contribution to journalEditorial

    2 Citations (Scopus)

    In vivo knockdown of antisense non-coding mitochondrial RNAs by a lentiviral-encoded shRNA inhibits melanoma tumor growth and lung colonization

    Varas-Godoy, M., Lladser, A., Farfan, N., Villota, C., Villegas, J., Tapia, J. C., Burzio, L. O., Burzio, V. A. & Valenzuela, P. D. T., 1 Jan 2017, (Accepted/In press) In : Pigment Cell and Melanoma Research. 31, 1, p. 64-72 9 p.

    Research output: Contribution to journalArticle

    Antisense RNA
    Untranslated RNA
    Small Interfering RNA
    Tumors
    Melanoma
    6 Citations (Scopus)

    Mitochondrial ASncmtRNA-1 and ASncmtRNA-2 as potent targets to inhibit tumor growth and metastasis in the RenCa murine renal adenocarcinoma model

    Borgna, V., Villegas, J., Burzio, V. A., Belmar, S., Araya, M., Jeldes, E., Lobos-González, L., Silva, V., Villota, C., Oliveira-Cruz, L., Lopez, C., Socias, T., Castillo, O. & Burzio, L. O., 2017, In : Oncotarget. 8, 27, p. 43692-43708 17 p.

    Research output: Contribution to journalArticle

    Renal Cell Carcinoma
    Antisense RNA
    Untranslated RNA
    Neoplasm Metastasis
    Growth

    Non-coding mitochondrial rnas (ncmtRNAs) in gynecological and urinary malignancies: Universal targets for development of an efficient therapy?

    Borgna, V., Lobos-González, L., Burzio, V., Araya, M., Ávila, R., Jeldes, E., Silva, V., Briones, M., Socias, T., Guevara, F., López, C., Villota, C., Bustamante, E., Bendex, M., Fitzpatrick, C., Burzio, L. O. & Villegas, J., 1 Jan 2017, Horizons in Cancer Research. Nova Science Publishers, Inc., Vol. 65. p. 91-117 27 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Untranslated RNA
    Long Noncoding RNA
    Antisense Oligonucleotides
    Neoplasms
    Therapeutics
    2016
    12 Citations (Scopus)

    Targeting antisense mitochondrial ncRNAs inhibits murine melanoma tumor growth and metastasis through reduction in survival and invasion factors

    Lobos-González, L., Silva, V., Araya, M., Restovic, F., Echenique, J., Oliveira-Cruz, L., Fitzpatrick, C., Briones, M., Villegas, J., Villota, C., Vidaurre, S., Borgna, V., Socias, M., Valenzuela, S., Lopez, C., Socias, T., Varas, M., Díaz, J., Burzio, L. O. & Burzio, V. A., 1 Jan 2016, In : Oncotarget. 7, 36, p. 58331-58350 20 p.

    Research output: Contribution to journalArticle

    Untranslated RNA
    Antisense RNA
    Melanoma
    Antisense Oligonucleotides
    Neoplasm Metastasis
    2014
    31 Citations (Scopus)

    Down-regulation of the antisense mitochondrial non-coding RNAs (ncRNAs) is a unique vulnerability of cancer cells and a potential target for cancer therapy

    Vidaurre, S., Fitzpatrick, C., Burzio, V. A., Briones, M., Villota, C., Villegas, J., Echenique, J., Oliveira-Cruz, L., Araya, M., Borgna, V., Socías, T., Lopez, C., Avila, R. & Burzio, L. O., 26 Sep 2014, In : Journal of Biological Chemistry. 289, 39, p. 27182-27198 17 p.

    Research output: Contribution to journalArticle

    Untranslated RNA
    Down-Regulation
    Cells
    Cell death
    Tumors
    1 Citation (Scopus)

    Long non coding mitochondrial RNAs as potential targets for diagnosis and therapy of bladder cancer

    Villegas, J., Rivas, A., Ávila, R., Borgna, V., Lobos-Gonzales, L., Burzio, V., López, C., Gomez, R., Landerer, E., Velarde, L. & Burzio, L. O., 1 Jan 2014, Bladder Cancer. Nova Science Publishers, Inc., p. 95-116 22 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Long Noncoding RNA
    Urinary Bladder Neoplasms
    Neoplasms
    Therapeutics
    Down-Regulation

    Long non-coding mitochondrial RNAs as potential targets for diagnosis and therapy of bladder cancer

    Villegas, J., Rivas, A., Ávila, R., Borgna, V., Lobos-Gonzales, L., Burzio, V., López, C., Gomez, R., Landerer, E., Velarde, L. & Burzio, L. O., 2014, In : International Journal of Cancer Research and Prevention. 7, 2, p. 147-162 16 p.

    Research output: Contribution to journalArticle

    Long Noncoding RNA
    Urinary Bladder Neoplasms
    Neoplasms
    Therapeutics
    Intravesical Administration
    2012
    21 Citations (Scopus)

    Determination of the differential expression of mitochondrial long non-coding RNAs as a noninvasive diagnosis of bladder cancer

    Rivas, A., Burzio, V., Landerer, E., Borgna, V., Gatica, S., Ávila, R., López, C., Villota, C., De La Fuente, R., Echenique, J., Burzio, L. O. & Villegas, J., 2012, In : BMC Urology. 12, 37.

    Research output: Contribution to journalArticle

    Long Noncoding RNA
    Urinary Bladder Neoplasms
    Urine
    Tissue Donors
    Fluorescence In Situ Hybridization
    22 Citations (Scopus)

    Expression of mitochondrial non-coding RNAs (ncRNAs) is modulated by high risk human papillomavirus (HPV) oncogenes

    Villota, C., Campos, A., Vidaurre, S., Oliveira-Cruz, L., Boccardo, E., Burzio, V. A., Varas, M., Villegas, J., Villa, L. L., Valenzuela, P. D. T., Socías, M., Roberts, S. & Burzio, L. O., 15 Jun 2012, In : Journal of Biological Chemistry. 287, 25, p. 21303-21315 13 p.

    Research output: Contribution to journalArticle

    Untranslated RNA
    Oncogenes
    Oncogenic viruses
    Cells
    Cell proliferation
    2011
    40 Citations (Scopus)

    Nuclear localization of the mitochondrial ncRNAs in normal and cancer cells

    Landerer, E., Villegas, J., Burzio, V. A., Oliveira, L., Villota, C., Lopez, C., Restovic, F., Martinez, R., Castillo, O. & Burzio, L. O., Aug 2011, In : Cellular Oncology. 34, 4, p. 297-305 9 p.

    Research output: Contribution to journalArticle

    Neoplasms
    In Situ Hybridization
    Heterochromatin
    Ribonucleases
    Confocal Microscopy
    2009
    60 Citations (Scopus)

    Expression of a family of noncoding mitochondrial RNAs distinguishes normal from cancer cells

    Burzio, V. A., Villota, C., Villegas, J., Landerer, E., Boccardo, E., Villa, L. L., Martínez, R., Lopez, C., Gaete, F., Toro, V., Rodriguez, X. & Burzio, L. O., 9 Jun 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 23, p. 9430-9434 5 p.

    Research output: Contribution to journalArticle

    Untranslated RNA
    Neoplasms
    Tumor Cell Line
    Nucleotides
    Cell Culture Techniques
    2007
    40 Citations (Scopus)

    Expression of a novel non-coding mitochondrial RNA in human proliferating cells

    Villegas, J., Burzio, V., Villota, C., Landerer, E., Martinez, R., Santander, M., Martinez, R., Pinto, R., Vera, M. I., Boccardo, E., Villa, L. L. & Burzio, L. O., 1 Dec 2007, In : Nucleic Acids Research. 35, 21, p. 7336-7347 12 p.

    Research output: Contribution to journalArticle

    Untranslated RNA
    Nucleotides
    Aphidicolin
    Pancreatic Ribonuclease
    Phytohemagglutinins
    2003
    17 Citations (Scopus)

    The complete sequence of the mitochondrial genome of the Chinook salmon, Oncorhyncus tshawytscha

    Wilhelm, V., Villegas, J., Miquel, Á., Engel, E., Bernales, S., Valenzuela, P. D. T. & Burzio, L. O., 2003, In : Biological Research. 36, 2, p. 223-231 9 p.

    Research output: Contribution to journalArticle

    Mitochondrial Genome
    Trout
    Salmon
    Oncorhynchus tshawytscha
    Genes
    2002
    18 Citations (Scopus)

    A putative RNA editing from U to C in a mouse mitochondrial transcript

    Villegas, J., Müller, I., Arredondo, J., Pinto, R. & Burzio, L. O., 1 May 2002, In : Nucleic Acids Research. 30, 9, p. 1895-1901 7 p.

    Research output: Contribution to journalArticle

    RNA Editing
    RNA
    Genes
    DNA Restriction Enzymes
    Artifacts
    31 Citations (Scopus)

    Localization of the 16S mitochondrial rRNA in the nucleus of mammalian spermatogenic cells

    Villegas, J., Araya, P., Bustos-Obregon, E. & Burzio, L. O., 1 Nov 2002, In : Molecular Human Reproduction. 8, 11, p. 977-983 7 p.

    Research output: Contribution to journalArticle

    Spermatocytes
    Spermatogenesis
    In Situ Hybridization
    Spermatozoa
    Sperm Head
    2000
    20 Citations (Scopus)

    A novel chimeric mitochondrial RNA localized in the nucleus of mouse sperm

    Villegas, J., Zarraga, A. M., Muller, I., Montecinos, L., Werner, E., Brito, M., Meneses, A. M. & Burzio, L. O., 2000, In : DNA and Cell Biology. 19, 9, p. 579-588 10 p.

    Research output: Contribution to journalArticle

    Spermatozoa
    RNA
    Testis
    Clone Cells
    Trans-Splicing
    1997

    A novel mitochondrial rna containing the 16s rRNA is present in mouse sperm cells

    Villegas, J., Zarraga, A. M., Montecinos, L., Brito, M., Werner, E. & Burzio, L. O., 1997, In : FASEB Journal. 11, 9

    Research output: Contribution to journalArticle

    Spermatozoa
    RNA
    Cell proliferation
    In Situ Hybridization
    Sperm Midpiece