JAIME EDUARDO VILLEGAS OLAVARRIA

Bachelor in Biologicals Science, PhD in Sciences

    • 401 Citations
    • 12 h-Index
    19972020

    Research output per year

    If you made any changes in Pure these will be visible here soon.

    Research Output

    • 401 Citations
    • 12 h-Index
    • 21 Article
    • 2 Chapter
    • 1 Editorial
    2020

    Exosomes released upon mitochondrial ASncmtRNA knockdown reduce tumorigenic properties of malignant breast cancer cells

    Lobos-González, L., Bustos, R., Campos, A., Silva, V., Silva, V., Jeldes, E., Salomon, C., Varas-Godoy, M., Cáceres-Verschae, A., Duran, E., Vera, T., Ezquer, F., Ezquer, M., Burzio, V. A. & Villegas, J., 1 Dec 2020, In : Scientific Reports. 10, 1, 343.

    Research output: Contribution to journalArticle

    Open Access

    Gold nanoparticle based double-labeling of melanoma extracellular vesicles to determine the specificity of uptake by cells and preferential accumulation in small metastatic lung tumors

    Lara, P., Palma-Florez, S., Salas-Huenuleo, E., Polakovicova, I., Guerrero, S., Lobos-Gonzalez, L., Campos, A., Muñoz, L., Jorquera-Cordero, C., Varas-Godoy, M., Cancino, J., Arias, E., Villegas, J., Cruz, L. J., Albericio, F., Araya, E., Corvalan, A. H., Quest, A. F. G. & Kogan, M. J., 23 Jan 2020, In : Journal of Nanobiotechnology. 18, 1, 20.

    Research output: Contribution to journalArticle

    Open Access
    1 Citation (Scopus)

    Targeting antisense mitochondrial noncoding RNAs induces bladder cancer cell death and inhibition of tumor growth through reduction of survival and invasion factors

    Borgna, V., Lobos-González, L., Guevara, F., Landerer, E., Bendek, M., Ávila, R., Silva, V., Villota, C., Araya, M., Rivas, A., López, C., Socias, T., Castillo, J., Alarcón, L., Burzio, L. O., Burzio, V. A. & Villegas, J., 1 Jan 2020, In : Journal of Cancer. 11, 7, p. 1780-1791 12 p.

    Research output: Contribution to journalArticle

    Open Access
    2019

    HPV-18 E2 protein downregulates antisense noncoding mitochondrial RNA-2, delaying replicative senescence of human keratinocytes

    Villota, C., Varas-Godoy, M., Jeldes, E., Campos, A., Villegas, J., Borgna, V., Burzio, L. O. & Burzio, V. A., 1 Jan 2019, In : Aging. 11, 1, p. 33-47 15 p.

    Research output: Contribution to journalArticle

    1 Citation (Scopus)

    Mitochondrial ncRNA targeting induces cell cycle arrest and tumor growth inhibition of MDA-MB-231 breast cancer cells through reduction of key cell cycle progression factors

    Fitzpatrick, C., Bendek, M. F., Briones, M., Farfán, N., Silva, V. A., Nardocci, G., Montecino, M., Boland, A., Deleuze, J. F., Villegas, J., Villota, C., Silva, V., Lobos-Gonzalez, L., Borgna, V., Barrey, E., Burzio, L. O. & Burzio, V. A., 1 Jun 2019, In : Cell Death and Disease. 10, 6, 423.

    Research output: Contribution to journalArticle

    Open Access
    6 Citations (Scopus)
    2017

    Cervical cancer, human papillomavirus and vaccines: assessment of the information retrieved from general knowledge websites in Chile

    Lopez, C. S., Krauskopf, E., Villota, C. E., Burzio, L. O. & Villegas, J. E., 1 Jul 2017, In : Public Health. 148, p. 19-24 6 p.

    Research output: Contribution to journalArticle

    1 Citation (Scopus)

    Different cancers, same target?

    Villegas, J., Borgna, V. & Burzio, V. A., 1 Jan 2017, In : Aging. 9, 8, p. 1853-1854 2 p.

    Research output: Contribution to journalEditorial

    In vivo knockdown of antisense non-coding mitochondrial RNAs by a lentiviral-encoded shRNA inhibits melanoma tumor growth and lung colonization

    Varas-Godoy, M., Lladser, A., Farfan, N., Villota, C., Villegas, J., Tapia, J. C., Burzio, L. O., Burzio, V. A. & Valenzuela, P. D. T., 1 Jan 2017, (Accepted/In press) In : Pigment Cell and Melanoma Research. 31, 1, p. 64-72 9 p.

    Research output: Contribution to journalArticle

    6 Citations (Scopus)

    Mitochondrial ASncmtRNA-1 and ASncmtRNA-2 as potent targets to inhibit tumor growth and metastasis in the RenCa murine renal adenocarcinoma model

    Borgna, V., Villegas, J., Burzio, V. A., Belmar, S., Araya, M., Jeldes, E., Lobos-González, L., Silva, V., Villota, C., Oliveira-Cruz, L., Lopez, C., Socias, T., Castillo, O. & Burzio, L. O., 2017, In : Oncotarget. 8, 27, p. 43692-43708 17 p.

    Research output: Contribution to journalArticle

    12 Citations (Scopus)

    Non-coding mitochondrial rnas (ncmtRNAs) in gynecological and urinary malignancies: Universal targets for development of an efficient therapy?

    Borgna, V., Lobos-González, L., Burzio, V., Araya, M., Ávila, R., Jeldes, E., Silva, V., Briones, M., Socias, T., Guevara, F., López, C., Villota, C., Bustamante, E., Bendex, M., Fitzpatrick, C., Burzio, L. O. & Villegas, J., 1 Jan 2017, Horizons in Cancer Research. Nova Science Publishers, Inc., Vol. 65. p. 91-117 27 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

    2016

    Targeting antisense mitochondrial ncRNAs inhibits murine melanoma tumor growth and metastasis through reduction in survival and invasion factors

    Lobos-González, L., Silva, V., Araya, M., Restovic, F., Echenique, J., Oliveira-Cruz, L., Fitzpatrick, C., Briones, M., Villegas, J., Villota, C., Vidaurre, S., Borgna, V., Socias, M., Valenzuela, S., Lopez, C., Socias, T., Varas, M., Díaz, J., Burzio, L. O. & Burzio, V. A., 1 Jan 2016, In : Oncotarget. 7, 36, p. 58331-58350 20 p.

    Research output: Contribution to journalArticle

    15 Citations (Scopus)
    2014

    Down-regulation of the antisense mitochondrial non-coding RNAs (ncRNAs) is a unique vulnerability of cancer cells and a potential target for cancer therapy

    Vidaurre, S., Fitzpatrick, C., Burzio, V. A., Briones, M., Villota, C., Villegas, J., Echenique, J., Oliveira-Cruz, L., Araya, M., Borgna, V., Socías, T., Lopez, C., Avila, R. & Burzio, L. O., 26 Sep 2014, In : Journal of Biological Chemistry. 289, 39, p. 27182-27198 17 p.

    Research output: Contribution to journalArticle

    39 Citations (Scopus)

    Long non coding mitochondrial RNAs as potential targets for diagnosis and therapy of bladder cancer

    Villegas, J., Rivas, A., Ávila, R., Borgna, V., Lobos-Gonzales, L., Burzio, V., López, C., Gomez, R., Landerer, E., Velarde, L. & Burzio, L. O., 1 Jan 2014, Bladder Cancer. Nova Science Publishers, Inc., p. 95-116 22 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Long non-coding mitochondrial RNAs as potential targets for diagnosis and therapy of bladder cancer

    Villegas, J., Rivas, A., Ávila, R., Borgna, V., Lobos-Gonzales, L., Burzio, V., López, C., Gomez, R., Landerer, E., Velarde, L. & Burzio, L. O., 2014, In : International Journal of Cancer Research and Prevention. 7, 2, p. 147-162 16 p.

    Research output: Contribution to journalArticle

    2012

    Determination of the differential expression of mitochondrial long non-coding RNAs as a noninvasive diagnosis of bladder cancer

    Rivas, A., Burzio, V., Landerer, E., Borgna, V., Gatica, S., Ávila, R., López, C., Villota, C., De La Fuente, R., Echenique, J., Burzio, L. O. & Villegas, J., 2012, In : BMC Urology. 12, 37.

    Research output: Contribution to journalArticle

    27 Citations (Scopus)

    Expression of mitochondrial non-coding RNAs (ncRNAs) is modulated by high risk human papillomavirus (HPV) oncogenes

    Villota, C., Campos, A., Vidaurre, S., Oliveira-Cruz, L., Boccardo, E., Burzio, V. A., Varas, M., Villegas, J., Villa, L. L., Valenzuela, P. D. T., Socías, M., Roberts, S. & Burzio, L. O., 15 Jun 2012, In : Journal of Biological Chemistry. 287, 25, p. 21303-21315 13 p.

    Research output: Contribution to journalArticle

    31 Citations (Scopus)
    2011

    Nuclear localization of the mitochondrial ncRNAs in normal and cancer cells

    Landerer, E., Villegas, J., Burzio, V. A., Oliveira, L., Villota, C., Lopez, C., Restovic, F., Martinez, R., Castillo, O. & Burzio, L. O., Aug 2011, In : Cellular Oncology. 34, 4, p. 297-305 9 p.

    Research output: Contribution to journalArticle

    46 Citations (Scopus)
    2009

    Expression of a family of noncoding mitochondrial RNAs distinguishes normal from cancer cells

    Burzio, V. A., Villota, C., Villegas, J., Landerer, E., Boccardo, E., Villa, L. L., Martínez, R., Lopez, C., Gaete, F., Toro, V., Rodriguez, X. & Burzio, L. O., 9 Jun 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 23, p. 9430-9434 5 p.

    Research output: Contribution to journalArticle

    70 Citations (Scopus)
    2007

    Expression of a novel non-coding mitochondrial RNA in human proliferating cells

    Villegas, J., Burzio, V., Villota, C., Landerer, E., Martinez, R., Santander, M., Martinez, R., Pinto, R., Vera, M. I., Boccardo, E., Villa, L. L. & Burzio, L. O., 1 Dec 2007, In : Nucleic Acids Research. 35, 21, p. 7336-7347 12 p.

    Research output: Contribution to journalArticle

    48 Citations (Scopus)
    2003

    The complete sequence of the mitochondrial genome of the Chinook salmon, Oncorhyncus tshawytscha

    Wilhelm, V., Villegas, J., Miquel, Á., Engel, E., Bernales, S., Valenzuela, P. D. T. & Burzio, L. O., 2003, In : Biological Research. 36, 2, p. 223-231 9 p.

    Research output: Contribution to journalArticle

    17 Citations (Scopus)
    2002

    A putative RNA editing from U to C in a mouse mitochondrial transcript

    Villegas, J., Müller, I., Arredondo, J., Pinto, R. & Burzio, L. O., 1 May 2002, In : Nucleic Acids Research. 30, 9, p. 1895-1901 7 p.

    Research output: Contribution to journalArticle

    20 Citations (Scopus)

    Localization of the 16S mitochondrial rRNA in the nucleus of mammalian spermatogenic cells

    Villegas, J., Araya, P., Bustos-Obregon, E. & Burzio, L. O., 1 Nov 2002, In : Molecular Human Reproduction. 8, 11, p. 977-983 7 p.

    Research output: Contribution to journalArticle

    35 Citations (Scopus)
    2000

    A novel chimeric mitochondrial RNA localized in the nucleus of mouse sperm

    Villegas, J., Zarraga, A. M., Muller, I., Montecinos, L., Werner, E., Brito, M., Meneses, A. M. & Burzio, L. O., 2000, In : DNA and Cell Biology. 19, 9, p. 579-588 10 p.

    Research output: Contribution to journalArticle

    26 Citations (Scopus)
    1997

    A novel mitochondrial rna containing the 16s rRNA is present in mouse sperm cells

    Villegas, J., Zarraga, A. M., Montecinos, L., Brito, M., Werner, E. & Burzio, L. O., 1997, In : FASEB Journal. 11, 9

    Research output: Contribution to journalArticle